Fig. 2

Schematic illustration describing pharmacokinetics and brain distribution of S-atenolol, and transformation of the microdialysis data by evaluating the probe recoveries. Solid arrows show mass transport between compartments (squares). Dashed arrows represent the transformations and corrections from observed dialysate data (ovals) to the unbound drug concentration in brain and plasma. Relative recoveries (REC), systemic total clearance (CL), clearance between arterial and peripheral compartments (Q), clearance between arterial and venous compartments (Q_AV), volume of distribution of the arterial compartment (V_A), volume of distribution of the venous compartment (Vv), volume of distribution of the peripheral compartment (V₂), unbound fraction in plasma (f_u,p), influx clearance into brain (CL_in), efflux clearance out of brain (CL_out), and unbound volume of distribution in brain (V_u,brain)