Dose escalation study of intravenous and intra-arterial N-acetylcysteine for the prevention of oto- and nephrotoxicity of cisplatin with a contrast-induced nephropathy model in patients with renal insufficiency

Table 2 Toxicities attributed to N-acetylcysteine

Group	Patient number	Weight (kg)	NAC dose (mg/kg)	NAC volume (mL)	NAC toxicity
IV	4_IV	84	300	126	Grade 1, facial erythema
	7_IV	98	600	294	Grade 4, respiratory and cardiac arrest
	10_IV	96	450	216	Grade 2, pruritus and rash
	11_IV	103	450	231.75	Grade 1, coughing
IA	1_IA	55	150	41.25	Grade 4^a, anaphylaxis
	8_IA	101	300	151.5	Grade 1, nausea
	10_IA	95	450	213.75	Grade 1, coughing
	11_IA	80	450	180	Grade 1, facial erythema

ISSN: 2045-8118