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Table 1 N-Acetylcysteine and contrast agent volumes, N-acetylcysteine administration time, baseline serum creatinine levels, and 5-min N-acetylcysteine and glutathione concentrations

From: Dose escalation study of intravenous and intra-arterial N-acetylcysteine for the prevention of oto- and nephrotoxicity of cisplatin with a contrast-induced nephropathy model in patients with renal insufficiency

Parameter

NAC dose (mg/kg)

IV group (Mean ± SD)

IA group (Mean ± SD)

p value

NAC volume (mL)

150

63.25 ± 50.61

51.88 ± 6.6

0.31

300

109.5 ± 6.89

132.5 ± 46.37

0.183

600

294

NA

NA

450

167.58 ± 44.63

166.13 ± 41.61

0.956

NAC administration time (min)

150

26.67 ± 2.89

31.67 ± 7.53

0.196

300

31.67 ± 5.77

38.33 ± 2.89

0.173

600

51

NA

NA

450

40 ± 6.32

42.5 ± 8.22

0.569

CA volume (mL)

150

94.33 ± 69.89

109.17 ± 56.16

0.768

300

80 ± 39.69

86.67 ± 64.29

0.887

600

0

NA

NA

450

89.5 ± 15.86

88.5 ± 25.81

0.937

Baseline serum creatinine (μmol/L)

150

201 ± 11.97

118.17 ± 15.53

0.402

300

123.67 ± 33.23

160 ± 24.76

0.343

600

157

NA

NA

450

209.33 ± 54.4

171.5 ± 52.89

0.486

NAC concentration at 5 min (mM)

150

0.43 ± 0.1

1.66 ± 0.32

< 0.001

300

1.04 ± 0.6

3.12 ± 0.77

0.023

600

4.53

NA

NA

450

2.03 ± 0.95

4.1 ± 1.22

0.009

GSH concentration at 5 min (mM)

150

0.13 ± 0.16

0.2 ± 0.04

0.514

300

0.13 ± 0.03

0.96 ± 0.36

0.058

600

0.21

NA

NA

450

0.19 ± 0.04

0.89 ± 0.31

0.003

  1. Italicized p-values indicate statistically significant values
  2. IV intravenous, IA intra-arterial, SD standard deviation, NAC N-acetylcysteine, NA not applicable, CA contrast agent, GSH glutathione