Parameter | NAC dose (mg/kg) | IV group (Mean ± SD) | IA group (Mean ± SD) | p value |
---|---|---|---|---|
NAC volume (mL) | 150 | 63.25 ± 50.61 | 51.88 ± 6.6 | 0.31 |
300 | 109.5 ± 6.89 | 132.5 ± 46.37 | 0.183 | |
600 | 294 | NA | NA | |
450 | 167.58 ± 44.63 | 166.13 ± 41.61 | 0.956 | |
NAC administration time (min) | 150 | 26.67 ± 2.89 | 31.67 ± 7.53 | 0.196 |
300 | 31.67 ± 5.77 | 38.33 ± 2.89 | 0.173 | |
600 | 51 | NA | NA | |
450 | 40 ± 6.32 | 42.5 ± 8.22 | 0.569 | |
CA volume (mL) | 150 | 94.33 ± 69.89 | 109.17 ± 56.16 | 0.768 |
300 | 80 ± 39.69 | 86.67 ± 64.29 | 0.887 | |
600 | 0 | NA | NA | |
450 | 89.5 ± 15.86 | 88.5 ± 25.81 | 0.937 | |
Baseline serum creatinine (μmol/L) | 150 | 201 ± 11.97 | 118.17 ± 15.53 | 0.402 |
300 | 123.67 ± 33.23 | 160 ± 24.76 | 0.343 | |
600 | 157 | NA | NA | |
450 | 209.33 ± 54.4 | 171.5 ± 52.89 | 0.486 | |
NAC concentration at 5 min (mM) | 150 | 0.43 ± 0.1 | 1.66 ± 0.32 | < 0.001 |
300 | 1.04 ± 0.6 | 3.12 ± 0.77 | 0.023 | |
600 | 4.53 | NA | NA | |
450 | 2.03 ± 0.95 | 4.1 ± 1.22 | 0.009 | |
GSH concentration at 5 min (mM) | 150 | 0.13 ± 0.16 | 0.2 ± 0.04 | 0.514 |
300 | 0.13 ± 0.03 | 0.96 ± 0.36 | 0.058 | |
600 | 0.21 | NA | NA | |
450 | 0.19 ± 0.04 | 0.89 ± 0.31 | 0.003 |