Table 2 Association between ventriculomegaly and cerebrospinal fluid flow with clinical, cerebrospinal fluid and neuroimaging characteristics
Characteristics | Ventriculomegaly | CSF stroke volume | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Evans’ index | Third ventricle width (mm) | Callosal angle (°) | Aqueductal (ml/CC) | C2–C3 (ml/CC) | |||||||||||
>0.3 n = 15 | ≤0.3 n = 28 | p | >10 n = 14 | ≤10 n = 29 | p | <90 n = 8 | ≥90 n = 35 | p | >0.05 n = 11 | ≤0.05 n = 31 | p | >0.5 n = 7 | ≤0.5 n = 35 | p | |
Age (years) | 9 (2–30) | 12 (1–36) | 0.483 | 10 (2–30) | 12 (1–36) | 0.577 | 9 (2–26) | 12 (1–36) | 0.502 | 6 (1–31) | 12 (1–36) | 0.229 | 12 (1–31) | 10 (1–36) | 0.774 |
Male sex | 11 (73.3) | 14 (50.0) | 0.199 | 12 (85.7) | 13 (44.8) | 0.019 | 6 (75.0) | 19 (54.3) | 0.434 | 8 (72.7) | 16 (51.6) | 0.299 | 5 (71.4) | 19 (54.3) | 0.679 |
Type | 0.709 | 0.373 | 0.333 | 0.183 | >0.99 | ||||||||||
I | 4 (26.7) | 8 (28.6) | 3 (21.4) | 9 (31.0) | 2 (25.0) | 10 (28.6) | 3 (27.3) | 8 (25.8) | 2 (28.6) | 9 (25.7) | |||||
II | 7 (46.7) | 8 (28.6) | 7 (50.0) | 8 (27.6) | 5 (62.5) | 10 (28.6) | 6 (54.5) | 9 (29.0) | 4 (57.1) | 11 (31.4) | |||||
III | 1 (6.7) | 4 (14.3) | 2 (14.3) | 3 (10.3) | 1 (12.5) | 4 (11.4) | 2 (18.2) | 3 (9.7) | 1 (14.3) | 4 (11.4) | |||||
IV | 2 (13.3) | 7 (25.0) | 1 (7.1) | 8 (27.6) | 0 (0.0) | 9 (25.7) | 0 (0.0) | 9 (29.0) | 0 (0.0) | 9 (25.7) | |||||
VI | 1 (6.7) | 1 (3.6) | 1 (7.1) | 1 (3.4) | 0 (0.0) | 2 (5.7) | 0 (0.0) | 2 (6.5) | 0 (0.0) | 2 (5.7) | |||||
Severe form | 9 (60.0) | 4 (14.3) | 0.004 | 8 (57.1) | 5 (17.2) | 0.013 | 6 (75.0) | 7 (20.0) | 0.006 | 6 (54.5) | 7 (22.6) | 0.066 | 2 (28.6) | 11 (31.4) | >0.99 |
Macrocephaly | 9 (60.0) | 5 (17.9) | 0.008 | 8 (57.1) | 6 (20.7) | 0.035 | 5 (62.5) | 9 (25.7) | 0.089 | 6 (54.5) | 7 (22.6) | 0.066 | 2 (28.6) | 11 (31.4) | >0.99 |
CI | 10 (66.7) | 8/27 (29.6) | 0.027 | 10 (71.4) | 8/28 (28.6) | 0.019 | 6 (75.0) | 12/34 (35.3) | 0.056 | 6 (54.5) | 11/30 (36.7) | 0.476 | 4 (57.1) | 13/34 (38.2) | 0.421 |
eCSF protein | 6/12 (50.0) | 12/25 (48.0) | >0.99 | 5/12 (41.7) | 13/25 (52.0) | 0.728 | 3/7 (42.9) | 15/30 (50.0) | >0.99 | 2 (18.2) | 15/25 (60.0) | 0.031 | 2/6 (33.3) | 15/30 (50.0) | 0.662 |
eCSF GAGs | 8/12 (66.7) | 13/25 (52.0) | 0.491 | 9/12 (75.0) | 12/25 (48.0) | 0.166 | 5/7 (71.4) | 16/30 (53.3) | 0.674 | 8 (72.7) | 13/25 (52.0) | 0.295 | 4/6 (66.7) | 17/30 (56.7) | >0.99 |
dPVS | 14 (93.3) | 15 (53.6) | 0.015 | 14 (100.0) | 15 (51.7) | 0.001 | 7 (87.5) | 22 (62.9) | 0.240 | 11 (100.0) | 17 (54.8) | 0.007 | 7 (100.0) | 21 (60.0) | 0.075 |
eWML load | 12/14 (85.7) | 9 (32.1) | 0.003 | 11/13 (84.6) | 10 (34.5) | 0.006 | 8 (100.0) | 13/34 (38.2) | 0.003 | 7 (63.6) | 14 (45.2) | 0.484 | 2 (28.6) | 19 (54.3) | 0.410 |
SCC | 10 (66.7) | 20 (71.4) | 0.742 | 9 (64.3) | 21 (72.4) | 0.726 | 4 (50.0) | 26 (74.3) | 0.217 | 6 (54.5) | 23 (74.2) | 0.270 | 3 (42.9) | 26 (74.3) | 0.176 |