Correlation of CSF flow using phase-contrast MRI with ventriculomegaly and CSF opening pressure in mucopolysaccharidoses

Table 1 Correlation between ventricular and CSF volume measurements, and CSF opening pressure, CSF flow and neuroimaging findings

	CSF OP			ACSV			C2–C3 CSF SV			Dilated PVS			WML load			CCJ stenosis
	r _s	p	p′	r _s	p	p′	r _s	p	p′	r _s	p	p′	r _s	p	p′	r _s	p	p′
Evans’ index	−0.08	0.646	0.702	0.35	0.023	0.040	−0.05	0.762	0.813	0.39	0.011	0.019	0.51	0.001	0.004	−0.01	0.933	0.933
TVW	−0.29	0.073	0.412	0.46	0.002	0.014	−0.12	0.469	0.773	0.54	<0.001	0.003	0.34	0.030	0.052	−0.08	0.619	0.730
Callosal angle	0.06	0.721	0.721	−0.46	0.002	0.014	−0.20	0.204	0.773	−0.35	0.020	0.028	−0.54	<0.001	0.003	0.18	0.262	0.508
Brain volume	0.27	0.113	0.412	−0.13	0.418	0.468	0.21	0.191	0.773	−0.33	0.033	0.038	−0.01	0.975	0.975	0.13	0.426	0.622
TCSF volume	−0.18	0.300	0.460	0.29	0.071	0.098	0.09	0.596	0.773	0.49	0.001	0.004	0.26	0.097	0.133	−0.30	0.054	0.177
VCSF volume	−0.10	0.577	0.700	0.46	0.002	0.014	0.01	0.941	0.941	0.55	<0.001	0.003	0.51	0.001	0.004	−0.08	0.607	0.730
SACSF volume	−0.26	0.124	0.412	0.06	0.694	0.694	0.16	0.325	0.773	0.29	0.071	0.071	0.03	0.871	0.908	−0.37	0.016	0.107

Data are presented as Spearman’s rank correlation coefficient (r_s), p value and adjusted p (p′) using Finner’s adjustment procedure
Italic values indicate significance of p value (p < 0.05)
CSF cerebrospinal fluid, CSF OP cerebrospinal fluid opening pressure, ACSV aqueductal cerebrospinal fluid stroke volume, C2–C3 CSF SV C2–C3 cerebrospinal fluid stroke volume, PVS perivascular spaces, WML white matter lesion, CCJ craniocervical junction, TVW third ventricle width, TCSF total cerebrospinal fluid, VCSF ventricular cerebrospinal fluid, SACSF subarachnoid cerebrospinal fluid

ISSN: 2045-8118