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Fig. 5 | Fluids and Barriers of the CNS

Fig. 5

From: Barrier dysfunction or drainage reduction: differentiating causes of CSF protein increase

Fig. 5

Impact of changes in CSF pulsation amplitude on the steady state albumin quotient distribution. x is the normalized location on the rostro-caudal spinal axis from lumbar (x = 0) to cervical space (x = 1) in Fig. 3a. The solid black line represents the nominal condition with CSF velocity pulsation amplitude of 10 mm/s (dispersion coefficient of 6 · 10−8 m2/s), the red dashed and blue dashed-dotted lines represent conditions with a factor of four pulsation amplitude reduction or increase, respectively (dispersion coefficients: 6 · 10−8 and 3.6 · 10−8 m2/s, respectively). Higher CSF velocity amplitudes reduce albumin gradients in the spinal cerebrospinal fluid space

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