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Table 6 Multivariable-adjusted regression models in the subset of CHARTER study participants (N = 110) who had available, matched CSF and serum albumin measurements

From: Cerebrospinal fluid (CSF) biomarkers of iron status are associated with CSF viral load, antiretroviral therapy, and demographic factors in HIV-infected adults

Iron biomarker or covariate

Multivariable-adjusted β (95% CI)

p-value

CSF iron

 Age

−0.014 (−0.055, 0.027)

n.s.

 Sex (women vs. men)

0.258 (−0.347, 0.864)

n.s.

 Race/ethnicitya

0.732 (0.108, 1.36)

0.02

 Detectable plasma virus (Y vs. N)

0.611 (−0.022, 1.24)

0.06b

 Log10 (CSF HIV RNA concentration)

−0.581 (−1.09, −0.072)

0.03

 ART on vs. off

0.234 (−0.544, 1.01)

n.s.

 QAlb

0.215 (0.023, 0.407)

0.03

 Comorbidity (mild-moderate vs. minimal)

0.098 (−0.466, 0.661)

n.s.

CSF transferrin

 Age

0.005 (−0.016, 0.025)

n.s.

 Sex (women vs. men)

−0.389 (−0.750, −0.029)

0.03

 Race/ethnicity

−0.100 (−0.202, 0.002)

0.06 b

 Detectable plasma virus (Y vs. N)

−0.322 (−0.736, 0.090)

n.s.

 Log10 (CSF HIV RNA concentration)

0.380 (0.001, 0.760)

0.05 c

 ART on vs. off

0.801 (0.067, 1.54)

0.03

 Current ZDV use (Y vs. N)

0.009 (−0.364, 0.381)

n.s.

 QAlb

0.723 (0.346, 1.10)

<0.01

 Comorbidity (mild-moderate vs. minimal)

0.007 (−0.299, 0.313)

n.s.

CSF H-ferritin

 Age

0.734 (−0.438, 1.91)

n.s.

 Sex (women vs. men)

0.022 (−0.482, 0.487)

n.s.

 Race/ethnicity

−0.036 (−0.378, 0.305)

n.s.

 Detectable plasma virus (Y vs. N)

−0.407 (−0.780, −0.033)

0.03

 Log10 (CSF HIV RNA concentration)

0.277 (−0.129, 0.683)

n.s.

 ART on vs. off

0.688 (−0.197,1.57)

n.s.

 QAlb

0.084 (−0.006, 0.173)

n.s.

 Comorbidity (mild-moderate vs. minimal)

0.416 (0.038, 0.793)

0.03

  1. For each biomarker, all covariates in the regression model, including CSF: serum albumin ratio (QAlb), are shown. Biomarker values were (natural) log-transformed for all analyses
  2. aSelf-reported Hispanics or non-Hispanic Whites vs. Blacks
  3. b p-value = 0.057
  4. c p-value = 0.049