Skip to main content

Advertisement

Table 6 Multivariable-adjusted regression models in the subset of CHARTER study participants (N = 110) who had available, matched CSF and serum albumin measurements

From: Cerebrospinal fluid (CSF) biomarkers of iron status are associated with CSF viral load, antiretroviral therapy, and demographic factors in HIV-infected adults

Iron biomarker or covariate Multivariable-adjusted β (95% CI) p-value
CSF iron
 Age −0.014 (−0.055, 0.027) n.s.
 Sex (women vs. men) 0.258 (−0.347, 0.864) n.s.
 Race/ethnicitya 0.732 (0.108, 1.36) 0.02
 Detectable plasma virus (Y vs. N) 0.611 (−0.022, 1.24) 0.06b
 Log10 (CSF HIV RNA concentration) −0.581 (−1.09, −0.072) 0.03
 ART on vs. off 0.234 (−0.544, 1.01) n.s.
 QAlb 0.215 (0.023, 0.407) 0.03
 Comorbidity (mild-moderate vs. minimal) 0.098 (−0.466, 0.661) n.s.
CSF transferrin
 Age 0.005 (−0.016, 0.025) n.s.
 Sex (women vs. men) −0.389 (−0.750, −0.029) 0.03
 Race/ethnicity −0.100 (−0.202, 0.002) 0.06 b
 Detectable plasma virus (Y vs. N) −0.322 (−0.736, 0.090) n.s.
 Log10 (CSF HIV RNA concentration) 0.380 (0.001, 0.760) 0.05 c
 ART on vs. off 0.801 (0.067, 1.54) 0.03
 Current ZDV use (Y vs. N) 0.009 (−0.364, 0.381) n.s.
 QAlb 0.723 (0.346, 1.10) <0.01
 Comorbidity (mild-moderate vs. minimal) 0.007 (−0.299, 0.313) n.s.
CSF H-ferritin
 Age 0.734 (−0.438, 1.91) n.s.
 Sex (women vs. men) 0.022 (−0.482, 0.487) n.s.
 Race/ethnicity −0.036 (−0.378, 0.305) n.s.
 Detectable plasma virus (Y vs. N) −0.407 (−0.780, −0.033) 0.03
 Log10 (CSF HIV RNA concentration) 0.277 (−0.129, 0.683) n.s.
 ART on vs. off 0.688 (−0.197,1.57) n.s.
 QAlb 0.084 (−0.006, 0.173) n.s.
 Comorbidity (mild-moderate vs. minimal) 0.416 (0.038, 0.793) 0.03
  1. For each biomarker, all covariates in the regression model, including CSF: serum albumin ratio (QAlb), are shown. Biomarker values were (natural) log-transformed for all analyses
  2. aSelf-reported Hispanics or non-Hispanic Whites vs. Blacks
  3. b p-value = 0.057
  4. c p-value = 0.049