Fig. 3

As well as being a potential site of injury after stroke, the choroid plexus (CP) also responds to stroke in multiple ways that may modify brain injury. It should be noted that the potential protective CP responses may be elicited by injury distant from the CP, indicating an unknown signaling mechanism. While most of the CP responses are thought to be protective, the effects of leukocyte diapedesis and changes in CSF production (if any) are uncertain. Elucidation of protective mechanisms involving the CP led to studies where CPs or CP epithelial cell transplants were used in animals with ischemic stroke with evidence of neuroprotection