Fig. 2

In animal studies, there is evidence that both transient global cerebral ischemia and focal cerebral ischemia cause choroid plexus (CP) injury and blood-CSF barrier (BSCFB) disruption. There is evidence that the damage after global ischemia is quickly repaired and this probably involves shedding of damaged cells resulting in CP atrophy. This has not been examined in focal cerebral ischemia. In humans, the effects of transient global cerebral ischemia (e.g. cardiac arrest) on the CP have not been examined. There are very rare reports of CP infarcts after focal cerebral ischemia in patients, but the occurrence of CP damage after focal cerebral ischemia is almost certainly limited by the rich collateral circulation to the CP