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Fig. 2 | Fluids and Barriers of the CNS

Fig. 2

From: Nrf2 signaling increases expression of ATP-binding cassette subfamily C mRNA transcripts at the blood–brain barrier following hypoxia-reoxygenation stress

Fig. 2

H/R induces nuclear translocation of Nrf2 in rat brain microvessels. EMSA experiments (left-hand panel) show band shift to a higher molecular weight and an increase in band intensity in brain microvessels from female Sprague–Dawley rats subjected to H/R (H = 6% O2, 1 h; R = 21% O2 for 10 min, 30 min or 1 h) and hypoxic (Hx) animals, as well as those treated with sulforaphane. The right-hand panel shows data from EMSA experiments conducted in the presence of an excess (×200) of unlabeled probe. Image depicts a representative blot from three separate experiments

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Fluids and Barriers of the CNS

ISSN: 2045-8118