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Table 3 A comparison of MRZR studies in multiple sclerosis patients

From: The MRZ reaction in primary progressive multiple sclerosis

Study

Number of MS patients (MS subtypes)

Positive MRZR-2

Positive MRZR-1

Present study

n = 203 (PPMS: n = 103, RRMS: n = 100)

49%

76%

Reiber et al. [15]

n = 177 (no data concerning subtype)

[67%]

89%

Felgenhauer et al. [5]

n = 100 (no data concerning subtype)

[72%]

94%

Rosche et al. [24]

n = 68 (RRMS: n = 61, CIS: n = 7)

58%

[n.a.]

Brettschneider et al. [12]

n = 49 (CIS patients who converted to MS within 2 years)

47%

[n.a.]

Brecht et al.a [19]

n = 46 (RRMS: n = 26, SPMS: n = 12, PPMS: n = 8)

[24%]

46%

Jarius et al. [7]

n = 42 (RRMS: n = 29, SPMS: n = 4, CIS: n = 9)

88%

[n.a.]

Bednarova et al. [10]

n = 42 (no data concerning subtype)

[47%]

88%

Hottenrott et al. [9]

n = 33 (RRMS: n = 14, SPMS: n = 5, PPMS: n = 14)

70%

[82%]

Kulakowska et al.b [22]

n = 27 (RRMS: n = 21, PPMS: n = 6)

[56%]

81%

Tumani et al. [23]

n = 26 (no data concerning subtype)

[n.a.]

73%

Robinson-Agramonte et al. [21]

n = 23 (incomplete data concerning subtype)

[48%]

100%

  1. The studies are presented in descending order of number of patients
  2. Numbers in brackets were calculated by the author from data available in the respective article where possible
  3. MRZR-1 one or more positive antibody indices (AI) for measles (M), rubella (R) and varicella zoster (Z), MRZR-2 two or more positive AI, CIS clinical isolated syndrome, SPMS secondary progressive multiple sclerosis, PPMS primary progressive multiple sclerosis, RRMS relapsing-remitting multiple sclerosis, n.a. not available
  4. aThis study investigated only OCB-negative MS patients
  5. bThis study included AI for HSV