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Table 1 Demographics of patients at baseline

From: A change in brain white matter after shunt surgery in idiopathic normal pressure hydrocephalus: a tract-based spatial statistics study

Variables

INPH (n = 20)

INPH (n = 8)

df

p valuea

Responder (SR)

Non-responder (SNR)

Age in years, mean (SD)

75.5 (5.2)

76.6 (3.9)

26

NS

Sex, female/male

8/12

1/7

1

0.023

Education years, mean (SD)

10.4 (2.9)

8.8 (3.2)

26

NS

CSF shunt placement (VP/LP)

13/7

6/2

1

NS

TUG, mean (SD)

    

 Time to complete (s)

14.7 (4.1)

15.6 (3.1)

26

NS

 Number of steps

21.9 (7.0)

22.6 (4.0)

26

NS

iNPHGS, median (range)

    

 Gait disturbance

2.0 (2–3)

2.0 (1–4)

 

NS

 Cognitive disturbance

3.0 (0–3)

2.5 (1–3)

 

NS

 Urinary disturbance

1.5 (0–3)

2.0 (0–4)

 

NS

 Total

6.5 (2–9)

7.0 (4–9)

 

NS

 MMSE, mean (SD)

21.5 (4.6)

22.3 (5.1)

26

NS

 FAB, mean (SD)

10.7 (2.3)

12.9 (3.1)

26

NS

 Left VV/ICV ratio (%), mean (SD)

8.29 (1.99)

7.19 (1.64)

26

NS

 Left hemispheric FA, mean (SD)

0.386 (0.022)

0.380 (0.024)

26

NS

 Left hemispheric MD (×10−3 mm2/s), mean (SD)

0.813 (0.036)

0.829 (0.068)

26

NS

  1. INPH idiopathic normal pressure hydrocephalus, iNPHGS idiopathic normal pressure hydrocephalus grading scale, VP ventriculoperitoneal, LP lumboperitoneal, TUG Timed “Up and GO” test, MMSE Mini-Mental State Examination, FAB frontal assessment battery, Left VV/ICV ratio the ratio of the volume of the left lateral ventricle + the cerebral aqueduct + the left side region of the third and fourth ventricles and the volume of the left half intracranial space, FA fractional anisotropy, MD mean diffusivity, SD standard deviation, df degrees of freedom, NS not significant
  2. aPaired Student’s t test was used except for iNPHGS (Mann–Whitney U test)
  3. bPearson’s Chi squared test was used for sex and CSF shunt placement ratios