Fig. 1

Comparison of skeletons and mis-registrations observed in TBSS analysis. a Demonstrates the mean FA skeleton (green) derived from the study (the comparison between the patients with INPH and the healthy control subjects) and the FMRIB58 FA standard space skeleton (grey). The periventricular tracks in the mean FA skeleton (the internal capsules and the corpus callosum in particular) are out of position. b Shows a sample of mis-registration that occurred in the comparison of MD maps between the patients with INPH and the healthy control subjects. The back-projected voxels (red) in the columns, bodies, and crura of the bilateral fornixes were positioned on each side of the lateral ventricle, and those in a peri-Sylvian portion of the SWM of bilateral frontal operculums were on each side of the Sylvian fissure. A anterior, I inferior, L left, P posterior, S superior