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Fig. 15 | Fluids and Barriers of the CNS

Fig. 15

From: Fluid and ion transfer across the blood–brain and blood–cerebrospinal fluid barriers; a comparative account of mechanisms and roles

Fig. 15

Effects of Na+ or Cl− removal on pHi in the presence of CO2/HCO3 −. a When NaCl is replaced by n-methyl-d-glucosamine chloride, NMDG Cl, there is a progressive acidification of cells that is initially somewhat faster. Replacement of the Na+ allows pHi to recover. The dashed line indicates the drift in pHi observed when no substitution is made. It is attributed to the “leak” described in the text. This trace is the mean of four experiments. b When NaCl is replaced by Na gluconate there is a transient rapid alkalinization of the cells. This trace is from a single experiment. Both a and b are replotted from data sets used in [336]. Both effects are statistically significant, see Table 3 in [336]

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Fluids and Barriers of the CNS

ISSN: 2045-8118