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Fig. 10 | Fluids and Barriers of the CNS

Fig. 10

From: Fluid and ion transfer across the blood–brain and blood–cerebrospinal fluid barriers; a comparative account of mechanisms and roles

Fig. 10

Unidirectional Cl influx into parietal cortex as a function of [Cl]plasma. The Cl influx has been calculated as the transfer constant, k, taken from Fig. 3a in [269] times [Cl]plasma. The short-dashed curve is plotted using the expression for transport by a saturable transporter with k = V max /(K m  + [Cl]plasma), maximum transport rate, V max  = 250 mM s−1, and Michaelis constant, K m  = 43 mM as described by Smith and Rapoport [269]. The solid curve is the best fit for a model with a single saturable component plus an unsaturable component. 53% of the influx is unsaturable at [Cl]plasma = 118 mM. As shown by the long-dashed line, it is even possible to fit the data more closely than by Smith and Rapoport’s expression by assuming a high affinity, saturable component and an unsaturable component with 72% of the uptake unsaturable at 118 mM. The fitting is described in more detail in footnote 14

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