Table 1 Markers of dementia and protein concentrations in lumbar (fraction 1) and cistern-near cerebrospinal fluid (fraction 8) (n = 16 pairs of samples)
CSF protein (mg/l) | Albumin (mg/l) | Tau (pg/ml) | PTau (pg/ml) | Aβ1–42 (pg/ml) | Aβ1–40 (pg/ml) | Aβ1–42/Aβ1–40 | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Fraction | 1 | 8 | 1 | 8 | 1 | 8 | 1 | 8 | 1 | 8 | 1 | 8 | 1 | 8 |
Median | 433 | 353 | 253 | 202 | 188 | 210 | 26.5 | 27.0 | 985 | 955 | 12567 | 12576 | 0.077 | 0.075 |
25th percentile | 309 | 240 | 177 | 138 | 145 | 151 | 22.5 | 24.2 | 765 | 783 | 11215 | 11045 | 0.065 | 0.065 |
75th percentile | 513 | 427 | 288 | 234 | 280 | 265 | 35.0 | 36.3 | 1279 | 1191 | 15691 | 15465 | 0.088 | 0.087 |
Correlation between fraction 1 and 8 (r S ) | 0.95* | 0.91* | 0.94* | 0.98* | 0.97* | 0.93* | 0.81* | |||||||
Fraction 1 versus 8, p value; Wilcoxon signed rank test | <0.0001 | <0.0001 | NS | 0.02 | NS | NS | NS | |||||||