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Fig. 3 | Fluids and Barriers of the CNS

Fig. 3

From: Inhibition of ADAM10 promotes the clearance of Aβ across the BBB by reducing LRP1 ectodomain shedding

Fig. 3

LRP1 shedding in the brain and Aβ clearance across the BBB. Human Aβ42 (1 mM) was intracranially injected into ADAM10 endothelial KO and wild-type mice. Ten minutes after the injection, the brain and plasma were collected. The soluble fraction of the brain was probed for a LRP1 using an ELISA, while the plasma was probed for b Aβ42 using an ELISA. Values represent mean ± SEM (n = 8) and are expressed as amount of LRP1 per mg total protein or amount of Aβ42 per ml. Statistical analyses were performed using an unpaired t test

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