Fig. 3From: Inhibition of ADAM10 promotes the clearance of Aβ across the BBB by reducing LRP1 ectodomain sheddingLRP1 shedding in the brain and Aβ clearance across the BBB. Human Aβ42 (1 mM) was intracranially injected into ADAM10 endothelial KO and wild-type mice. Ten minutes after the injection, the brain and plasma were collected. The soluble fraction of the brain was probed for a LRP1 using an ELISA, while the plasma was probed for b Aβ42 using an ELISA. Values represent mean ± SEM (n = 8) and are expressed as amount of LRP1 per mg total protein or amount of Aβ42 per ml. Statistical analyses were performed using an unpaired t testBack to article page