Fig. 4
From: Directional cerebrospinal fluid movement between brain ventricles in larval zebrafish
Directionality of CSF movement is partially dependent on heartbeat at early larval stage. a Average vmax for movement between the telencephalon and diencephalon/mesencephalon at 27–30 hpf in wild type (WT; red) and tnnt2a −/− (pink) from the telencephalic-to-diencephalic/mesencephalic aqueduct or the posterior to anterior direction [blue (WT), light blue (tnnt2a −/−)]. b In tnnt2a −/− mutant fish there is no directionality of CSF movement observed through the diencephalic/mesencephalic -to-rhombencephalic aqueduct. WT data are from Fig. 3. Horizontal lines represent average vmax and error bars denote SEM. p value calculated using unpaired Student’s t test, **p < 0.001; ****p < 0.0001; n.s. not significant, T telencephalic ventricle, D/M diencephalic/mesencephalic ventricle, R rhombencephalic ventricle, hpf hours post-fertilization