Diffusion tensor imaging with direct cytopathological validation: characterisation of decorin treatment in experimental juvenile communicating hydrocephalus

Table 4 The marker of gliosis, GFAP, and AQP4 levels correlated with DTI parameter values in the periventricular white matter

ROI	Immunostain	DTI parameter	R	p
Corpus callosum	GFAP	FA	−0.370	0.144
		MD	0.306	0.232
		AD	0.600	0.011*
		RD	0.424	0.090*
	OX-42	FA	−0.086	0.743
		MD	0.002	0.993
		AD	0.352	0.165
		RD	0.120	0.646
	AQP4	FA	−0.323	0.205
		MD	0.191	0.462
		AD	0.566	0.018*
		RD	0.409	0.103
	MBP	FA	0.091	0.729
		MD	−0.031	0.903
		AD	0.159	0.541
		RD	−0.115	0.660
Periventricular white matter	GFAP	FA	−0.485	0.048*
		MD	0.647	0.005*
		AD	0.667	0.003*
		RD	0.680	0.003*
	OX-42	FA	−0.495	0.043*
		MD	0.292	0.256
		AD	0.299	0.244
		RD	0.213	0.411
	AQP4	FA	−0.640	0.006*
		MD	0.799	<0.001*
		AD	0.801	<0.001*
		RD	0.829	<0.001*
	MBP	FA	0.346	0.174
		MD	−0.495	0.043*
		AD	−0.360	0.155
		RD	−0.458	0.064*

FA fractional anisotropy, MD mean diffusivity, AD axial diffusivity, RD radial diffusivity, R the correlation coefficient
* Statistically significant correlations = p < 0.05

ISSN: 2045-8118