Fig. 2

Decorin reduced hydrocephalus induced abnormalities in the caudal corpus callosum and periventricular white matter as evident from DTI. a Representative FA images of the locations at which the corpus callosum and periventricular white matter were analysed. Section 1 (1.28 mm anterior to Bregma) and Section 2 (0.36 mm posterior to Bregma) are classified as the rostral periventricular white matter and corpus callosum. Section 3 (2.76 mm posterior to Bregma) and Section 4 (3.72 mm posterior to Bregma) refer to the caudal periventricular white matter and corpus callosum. Line graphs displaying decorin’s ability to reduce abnormalities in the (b) corpus callosum and (c) periventricular white matter on DTI; blue = Intact, green = kaolin, red = kaolin + PBS, orange = kaolin + decorin [Intact (n = 4), kaolin (n = 4), kaolin + PBS (n = 6), kaolin + decorin (n = 5)]. Error bars represent the standard error of the mean; *p < 0.05, **p < 0.01, ***p < 0.001