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Table 1 Results of magnesium sulfate treatment on hydrocephalic ferrets

From: Magnesium sulfate treatment for juvenile ferrets following induction of hydrocephalus with kaolin

  Non-hydrocephalic controls NaCl-treated hydrocephalus MgSO4-treated hydrocephalus
Sample size 2 7 6
Lateral ventricle area index (P29/pre-treat) 0.012 ± 0.002 0.147 ± 0.024* 0.155 ± 0.023*
Lateral ventricle area index (P45/post-treat) 0.006 ± 0.0005 0.219 ± 0.053*# 0.254 ± 0.046*#
Percent enlargement ventricles during treatment 48.9 ± 23.1 63.9 ± 24.4
Body weight (g) (P29/pre-treat) 148.0 ± 8.0 114.3 ± 4.8* 106.8 ± 9.1*
Body weight (g) (P45/post-treat) 264.5 ± 34.5# 288.3 ± 12.8# 170.0 ± 31.0*@#
Rearing activity (beam breaks per 3 min) (P43/post-treat) 71 ± 16 57 ± 15 22 ± 20*
Ambulatory activity (beam breaks per 3 min) (P43/post-treat) 541 ± 21 460 ± 44 321 ± 71*
Total activity (beam breaks per 3 min) (P43/post-treat) 684 ± 20 584 ± 54 443 ± 89*
Number cells entered—open field (per 3 min) (P43/post-treat) 88 ± 7 115 ± 12 111 ± 15
Distance traveled—open field (m per 3 min) (P43/post-treat) 5.64 ± 0.39 7.58 ± 0.95 7.11 ± 1.08
Medial corpus callosum thickness (μm) 965 ± 95 410 ± 71* 315 ± 97*
Lateral corpus callosum thickness (μm) 665 ± 45 330 ± 50* 245 ± 59*
MBP content frontal cerebrum (μg MBP/g protein) 72.19 ± 12.75 64.25 ± 19.66 56.07 ± 14.15
CGalT activity parietal cerebrum (nM/mg protein/h) 0.029 ± 0.008 0.075 ± 0.024 0.051 ± 0.014
GPC-PP activity parietal cerebrum (nM/mg protein/h) 15.25 ± 1.83 14.42 ± 0.90 11.64 ± 1.20
GFAP content frontal cerebrum (μg GFAP/g protein) 0.64 ± 0.02 0.90 ± 0.13 0.70 ± 0.12
Frontal cerebrum magnesium (μg Mg2+/g brain tissue) 133.64 ± 4.97 135.59 ± 10.37 150.89 ± 5.23
  1. All data are presented as mean ± SEM. Behavior and ventricle size are specified at by postnatal day (P) age. All brain structural and biochemical data are at P46
  2. CGalT ceramide galactosyltransferase
  3. GFAP glial fibrillary acidic protein
  4. GPC-PP glycerylphosphorylcholine phosphocholine phosphodiesterase
  5. MBP myelin basic protein
  6. * p < 0.05 control vs. hydrocephalic, t tests or ANOVA
  7. @ p < 0.05 NaCl vs. MgSO4-treated ferrets, t tests or ANOVA
  8. # p < 0.05 P29 (pre-treat) vs. P45 (post-treat), t tests