Fig. 7
From: Clearance from the mouse brain by convection of interstitial fluid towards the ventricular system
Different appearance of tracers around parenchymal vessels according to the injection site. a A case where tracers accumulated around an artery (A), after injection in the striatum. TR3 was taken up by smooth muscle ce6lls and parenchymal cells, whereas F500 was not. b Two parenchymal vessels showing F500 after injection in the cisterna magna. In this case the tracer entered the paravascular space from the CSF, but did not enter the parenchyma. We speculate that in panel a tracers were carried by bulk flow towards the artery, whereas in panel b the tracer entered the paravascular space as a result of the continuity with the SAS and the strong mixing action caused by pulsations in the CSF. Scale bar 50 µm