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Fig. 6 | Fluids and Barriers of the CNS

Fig. 6

From: Clearance from the mouse brain by convection of interstitial fluid towards the ventricular system

Fig. 6

Role of the vasculature in bulk flow. ac Cisterna magna injection, df striatum injection. Additional laminin staining is present in panels bf. a Tracers were found in the subarachnoid space, embedding arteries (a) and veins (v). Arteries showed additional red autofluorescence from elastin. Green arrows F-500 followed paravascular spaces along arteries into the parenchyma. b F-500 was prominent in cisterns, where large arteries entered the brain (green arrow). c F-500 entered the paravascular space of vessels from the ventral side of the brain (green arrows). d Small vessels close to the injection site did not show tracers. e Choroid plexus with TR-3 and F-500, adjacent veins (v) did not show tracers. f Both tracers followed blood vessels towards the brain surface. F-500 accumulated at the pia mater. Scale bar 100 µm

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