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Figure 3 | Fluids and Barriers of the CNS

Figure 3

From: Impact of cigarette smoke extract and hyperglycemic conditions on blood–brain barrier endothelial cells

Figure 3

Effects of hyperglycemic conditions, cigarette smoke extract and both combined exposure on BBB endothelial monolayer integrity. a CSE and HG-CSE but not HG elicited the release of VEGF (p < 0.01 for CSE, p < 0.001 for HG-CSE). b HG, CSE and HG + CSE induced a significant decrease of trans-endothelial electrical resistance (TEER). This is in agreement with a corresponding increased permeability to dextran molecules Rhod.B-ITC (70 kDa), Cascade blue (10 kDa) and FITC (3–4 kDa) as shown in c. n = 5 biological replicates. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001, *****p < 0.00001 vs. control and $ p < 0.05, $$ p < 0.01, $$$ p < 0.001 vs. HG.

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Fluids and Barriers of the CNS

ISSN: 2045-8118