Figure 6
Effects of low density lipoprotein (LDL) and oxLDL on the barrier integrity of co-culture BBB models. Effects of LDL or oxLDL treatment on the barrier integrity of BBB models from wild type (Wt) and ApoB-100 transgenic (Tg) mice. Brain endothelial cells co-cultured with pericytes and astroglia cells were treated for 24 h with LDL or oxLDL. A Permeability of mouse brain endothelial cell layers for Evans blue labeled albumin (EBA) is expressed as endothelial permeability coefficient (Pe, cm/s). B Transendothelial electrical resistance (TEER) is expressed as Ω cm2. C untreated control, OX oxLDL treatment. Values presented are mean ± SD, n = 3. Statistical analysis: ANOVA followed by Dunnett and Bonferroni post-tests. Statistically significant differences: (a) p < 0.05 compared to wild type control; (b) p < 0.05 compared to transgenic control.