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Table 1 Influx rate of D-glucose across blood–brain barrier in mice pre-infused with saline or nicotine and subjected to transient middle cerebral artery occlusion (tMCAO) or sham operation

From: Nicotine pre-exposure reduces stroke-induced glucose transporter-1 activity at the blood–brain barrier in mice

Animal group Saline infused Nicotine (4.5 mg/kg/day)
Sham tMCAO Sham tMCAO
Rate of influx (K in ) (mL.sec−1.g−1) 0.0026 ± 0.00069 0.0037 ± 0.00126# 0.0012 ± 0.00015** 0.0016 ± 0.00028***
  1. Data represent mean ± SEM, n = 5–6 animals, **P < 0.01 and ***P < 0.001 comparing the nicotine-infused group and the corresponding saline-infused sham group, # P < 0.05 comparing the nicotine-infused tMCAO group and saline-infused sham group using one way ANOVA analysis of the variance and Bonferonni’s multiple comparison test.