Nicotine pre-exposure reduces stroke-induced glucose transporter-1 activity at the blood–brain barrier in mice

Table 1 Influx rate of D-glucose across blood–brain barrier in mice pre-infused with saline or nicotine and subjected to transient middle cerebral artery occlusion (tMCAO) or sham operation

Animal group	Saline infused		Nicotine (4.5 mg/kg/day)
Animal group	Sham	tMCAO	Sham	tMCAO
Rate of influx (K _in) (mL.sec⁻¹.g⁻¹)	0.0026 ± 0.00069	0.0037 ± 0.00126^#	0.0012 ± 0.00015**	0.0016 ± 0.00028***

Data represent mean ± SEM, n = 5–6 animals, **P < 0.01 and ***P < 0.001 comparing the nicotine-infused group and the corresponding saline-infused sham group, ^# P < 0.05 comparing the nicotine-infused tMCAO group and saline-infused sham group using one way ANOVA analysis of the variance and Bonferonni’s multiple comparison test.

ISSN: 2045-8118