Pre-exposure to nicotine for 14 days reduces ischemic-reperfusion-enhanced glucose transporter (GLUT1) expression. (A) Effect of nicotine on brain microvascular GLUT1 expression in mouse brain. (B) Relative intensity of GLUT1 staining. Data represent mean ± SEM, n = 4–5, **P < 0.01 comparing the nicotine-infused group and the corresponding saline-infused sham group, #
P < 0.05 comparing the nicotine- infused tMCAO group and saline-infused sham group using one way ANOVA analysis of the variance and Bonferonni’s multiple comparison test.