MRI assessment of the effects of acetazolamide and external lumbar drainage in idiopathic Normal Pressure Hydrocephalus

Table 3 Effects of extended lumbar drainage (ELD) on radiologic and clinical metrics in patients with iNPH

ID	Age	Gender	CSF drainage (ml)	Ventricle vol. (mm ³ )		Cortical thickness		T1-hypo. vol. (mm ³ )		Symmetrized % Change		MMSE		10 m gait test (secs)		Mean ICP	Rout CSF	Improvement
ID	Age	Gender	CSF drainage (ml)	Before	After	mm	z-score	Before	After	MD	f ₀	Before	After	Before	After	(mmHg)	(mmHg/ml/min)	Improvement
ELD_1	70	male	410	282,634	252,228	2.38	1.3	21,772	18,966	8.3	5.2	26	20	na	na	11.2	14.7	Yes
ELD_2	76	male	515	222,300	189,744	2.15	0.3	37,581	34,730	7.1	5.3	26	27	na	29	11.7	22.8	Yes
ELD_3	75	male	640	89,100	54,547	2.30	1.0	9,921	5,896	14.1	6.4	29	25	24	23	5.3	3.4	Yes
ELD_4	65	male	516	165,969	159,925	2.21	−1.1	27,415	25,348	4.2	3.2	30	30	nm	nm	5.3	nm	Yes
ELD_5	74	female	350	129,471	120,182	2.38	1.5	17,427	15,244	6.4	0.8	17	20	22	13	9	21.6	Yes
ELD_6	76	male	487	112,852	106,816	2.20	0.9	6,692	6,732	6.0	3.1	30	30	14	13	8.5	14.9	Yes
ELD_7	73	female	583	162,758	155,040	2.37	1.4	18,451	15,975	11.2	4.2	30	29	15	14	9.8	12.8	Yes
ELD_8	70	male	398	103,008	104,376	1.85	−2.3	19,693	18,061	1.3	0.4	21	16	20	20	1.6	nm	No
ELD_9	76	female	566	73,976	74,968	2.17	−0.2	7,546	6,805	6.8	6.6	24	29	na	na	2.9	9.6	No
ELD_10	73	female	260	54,910	55,503	2.20	0.1	4,869	4,407	−2.4	−0.8	29	29	11	20	3.8	7.8	No
ELD_11	70	female	262	104,398	98,346	2.21	0.1	29,650	30,622	3.5	1.8	28	29	24	27	6.1	7.5	No
ELD_12	83	male	344	143,898	135,933	2.18	0.1	14,253	15,896	1.5	0.2	29	30	13	12	9.8	14.2	No

MD = mean diffusivity; f ₀ = isotropic diffusion fraction [20]; MMSE = Mini Mental Status Exam; ICP = intracranial pressure; Rout CSF = resistance to CSF drainage; na = not able to perform test; nm = not measured.

ISSN: 2045-8118