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Table 3 Effects of extended lumbar drainage (ELD) on radiologic and clinical metrics in patients with iNPH

From: MRI assessment of the effects of acetazolamide and external lumbar drainage in idiopathic Normal Pressure Hydrocephalus

ID Age Gender CSF drainage (ml) Ventricle vol. (mm 3 ) Cortical thickness T1-hypo. vol. (mm 3 ) Symmetrized % Change MMSE 10 m gait test (secs) Mean ICP Rout CSF Improvement
Before After mm z-score Before After MD f 0 Before After Before After (mmHg) (mmHg/ml/min)
ELD_1 70 male 410 282,634 252,228 2.38 1.3 21,772 18,966 8.3 5.2 26 20 na na 11.2 14.7 Yes
ELD_2 76 male 515 222,300 189,744 2.15 0.3 37,581 34,730 7.1 5.3 26 27 na 29 11.7 22.8 Yes
ELD_3 75 male 640 89,100 54,547 2.30 1.0 9,921 5,896 14.1 6.4 29 25 24 23 5.3 3.4 Yes
ELD_4 65 male 516 165,969 159,925 2.21 −1.1 27,415 25,348 4.2 3.2 30 30 nm nm 5.3 nm Yes
ELD_5 74 female 350 129,471 120,182 2.38 1.5 17,427 15,244 6.4 0.8 17 20 22 13 9 21.6 Yes
ELD_6 76 male 487 112,852 106,816 2.20 0.9 6,692 6,732 6.0 3.1 30 30 14 13 8.5 14.9 Yes
ELD_7 73 female 583 162,758 155,040 2.37 1.4 18,451 15,975 11.2 4.2 30 29 15 14 9.8 12.8 Yes
ELD_8 70 male 398 103,008 104,376 1.85 −2.3 19,693 18,061 1.3 0.4 21 16 20 20 1.6 nm No
ELD_9 76 female 566 73,976 74,968 2.17 −0.2 7,546 6,805 6.8 6.6 24 29 na na 2.9 9.6 No
ELD_10 73 female 260 54,910 55,503 2.20 0.1 4,869 4,407 −2.4 −0.8 29 29 11 20 3.8 7.8 No
ELD_11 70 female 262 104,398 98,346 2.21 0.1 29,650 30,622 3.5 1.8 28 29 24 27 6.1 7.5 No
ELD_12 83 male 344 143,898 135,933 2.18 0.1 14,253 15,896 1.5 0.2 29 30 13 12 9.8 14.2 No
  1. MD = mean diffusivity; f 0  = isotropic diffusion fraction [20]; MMSE = Mini Mental Status Exam; ICP = intracranial pressure; Rout CSF = resistance to CSF drainage; na = not able to perform test; nm = not measured.