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Table 1 Effects of acetazolamide (ACZ) on radiologic and clinical metrics in patients with iNPH

From: MRI assessment of the effects of acetazolamide and external lumbar drainage in idiopathic Normal Pressure Hydrocephalus

ID Age Gender Days between scans Ventricle vol. (mm 3 ) Cortical thickness T1 hypo. vol (mm 3 ) CBF (ml/100 ml/min) Symmetrized % change Boon score Improvement
Before After mm z-score Before After Before MD f 0 CBF Before After
ACZ_1 90 Male 83 125,124 124,758 2.08 −0.1 13,653 12,087 13.2 9.2 6 35 10 10 yes
ACZ_2 72 Female 143 77,447 76,605 2.02 −1.7 19,073 11,782 25.9 8.5 5.7 21 10 6 yes
ACZ_3 86 Male 86 123,287 122,220 2.09 −0.2 16,508 13,891 27.2 7 4.5 16 17 12 yes
ACZ_4* 80 Female 99 148,137 146,563 2.29 0.2 78,730 70,205 17.2 6.6 3 22 10 8/15* yes
ACZ_5 76 Male 112 163,105 165,388 2.42 1.7 13,930 13,196 15.8 4.1 2.4 17 12 4 yes
ACZ_6 82 Female 93 104,325 105,244 2.20 0.0 7,714 8,525 33.7 −1.6 −1 −9.6 12 14 no
ACZ_7 79 Male 136 176,078 176,778 1.99 −1.7 21,785 14,282 16.8 9.6 3.9 19 20 16 yes
ACZ_8 79 Female 111 111,200 109,500 2.23 0.1 23,437 19,114 20.6 10.4 9.6 2.9 11 9 yes
  1. *The patient suffered a stroke after the reported MRI scans. Her Boon score initially improved, but then worsened after the stroke.
  2. CBF = cerebral blood flow; f 0  = isotropic diffusion fraction [20]; MD = mean diffusivity.