MRI assessment of the effects of acetazolamide and external lumbar drainage in idiopathic Normal Pressure Hydrocephalus

Table 1 Effects of acetazolamide (ACZ) on radiologic and clinical metrics in patients with iNPH

ID	Age	Gender	Days between scans	Ventricle vol. (mm ³ )		Cortical thickness		T1 hypo. vol (mm ³ )		CBF (ml/100 ml/min)	Symmetrized % change			Boon score		Improvement
ID	Age	Gender	Days between scans	Before	After	mm	z-score	Before	After	Before	MD	f ₀	CBF	Before	After	Improvement
ACZ_1	90	Male	83	125,124	124,758	2.08	−0.1	13,653	12,087	13.2	9.2	6	35	10	10	yes
ACZ_2	72	Female	143	77,447	76,605	2.02	−1.7	19,073	11,782	25.9	8.5	5.7	21	10	6	yes
ACZ_3	86	Male	86	123,287	122,220	2.09	−0.2	16,508	13,891	27.2	7	4.5	16	17	12	yes
ACZ_4*	80	Female	99	148,137	146,563	2.29	0.2	78,730	70,205	17.2	6.6	3	22	10	8/15*	yes
ACZ_5	76	Male	112	163,105	165,388	2.42	1.7	13,930	13,196	15.8	4.1	2.4	17	12	4	yes
ACZ_6	82	Female	93	104,325	105,244	2.20	0.0	7,714	8,525	33.7	−1.6	−1	−9.6	12	14	no
ACZ_7	79	Male	136	176,078	176,778	1.99	−1.7	21,785	14,282	16.8	9.6	3.9	19	20	16	yes
ACZ_8	79	Female	111	111,200	109,500	2.23	0.1	23,437	19,114	20.6	10.4	9.6	2.9	11	9	yes

*The patient suffered a stroke after the reported MRI scans. Her Boon score initially improved, but then worsened after the stroke.
CBF = cerebral blood flow; f ₀ = isotropic diffusion fraction [20]; MD = mean diffusivity.

ISSN: 2045-8118