A subject with remarkable long-term correlation between cognitive scores and T1-hypointensities volume. Left: Correlation between Alzheimer’s Disease Assessment Scale (ADAS) cognitive scores and the volume of the white matter T1-hypointensities, over a 5 year period, for the Alzheimer’s Disease Neuroimaging Initiative (ADNI) subject 0644 (an MCI case). All the data points were independently calculated and available at the ADNI portal . Right: Hallmarks of CSF dysfunction on the same subject: ventriculomegaly and DESH pattern. Note lacunae in the deep gray matter, consistent with the radiologic presentation of dilated veins observed in untreated NPH patients .