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Table 1 CSF-restricted oligoclonal IgG, IgGκ, IgGλ, free κ and free λ bands

From: Detection of oligoclonal IgG kappa and IgG lambda bands in cerebrospinal fluid and serum with Hevylite™ antibodies. comparison with the free light chain oligoclonal pattern

No.

Diagnosis

Cells/μl

Albumin quotient (*103)

Intrathecal Ig fraction (%)

IgG(IF) (type)*

IgG(AIB)

IgGκ

IgGλ

IgGκ/IgGλ

fκ/fλ

1

MS

5

2.5

IgG 36%; IgM 30%

+ (type 3)

n.d.

+

+

+

+

=

=

2

MS

62

9.6

IgG 65%

+ (type 2)

n.d.

+

0

n.d.

n.d.

IgGκ only

n.d.

3

MS

5

2.9

IgG 30%, IgM 43%

+ (type 2)

n.d.

+

+

+

+

=

fκ > fλ

4

MS

5

4.5

IgG 65%

IgM 77%

+ (type 3)

+

+

+

+

+

=

=

5

MS

1

3.1

0

+ (type 3)

n.d.

+

+

n.d.

n.d.

=

n.d.

6

CIS

6

3.4

0

+ (type 2)

n.d.

0

+

+

+

IgGλ only

fκ > fλ

7

CIS

3

2.7

0

+ (type 3)

n.d.

+

+

+

+

=

fκ > fλ

8

CIS

1

3.3

0

+ (type 2)

+

+

+

+

+

IgGλ > IgGκ

=

9

NB

118

37.4

IgM 70%

+ (type 2)

+

+

+

+

+

IgGλ > IgGκ

=

10

NB

469

30.0

IgM 40%

+ (type 2)

+

+

+

+

+

IgGκ > IgGλ

fκ > fλ

11

NB + MGUS

145

30.0

IgG 30%

IgM 54%

+** (type 3 + type 5)

+**

+**

+

+

+

IgGλ > IgGκ

fκ > fλ

12

NB

35

12.8

0

0 (type 1)

0***

0***

0

+

0

1 IgGκ band only

fκ only

13

NB

100

32.8

IgM 42%

+ (type 3)

+

+

+

n.d.

n.d.

=

n.d.

14

AIDS, cerebral toxoplasmosis

7

10.5

IgM 53%

0 (type 4)

n.d.

+

+

+

+

=

fκ > fλ

15

AIDP

3

11.2

0

0 (type 4)

0

0

0

+

0

negative

fκ only

16

AIDP -1st puncture

1

51.5

0

0 (type 4)

0

0

0

+

+

negative

fκ > fλ

17

AIDP - 2nd puncture

1

39.4

0

0(type 4)

0

0

0

+

0

negative

fκ only

18

Oculomotor nerve paresis

3

6.7

0

0 (type 1)

n.d.

0

0

n.d.

n.d.

negative

n.d.

19

Neurodegenerative (parkinsonism)

2

6.2

0

0 (type 1)

0

0

0

+

0

negative

2 weak fκ bands

20

Tension headache

5

6.4

0

0 (type 1)

0

0

0

0

0

negative

negative

21

Dorsalgias, myalgias

0

5.3

0

0 (type 1)

0

0

0

0

0

negative

negative

22

Memory disturbance

0

3.0

0

0 (type 1)

0

0

0

0

0

negative

negative

23

Acute central hemiparesis with complete regression (post-paroxysmal?; normal brain MRI)

0

4.0

0

0 (type 4)

0

0

0

0

0

negative

negative

24

Posterior columns syndrome, unknown etiology

3

21.0

IgM 12%

0 (type 1)

0

0

0

+

0

negative

fκ only

25

Lacunar stroke

1

3.9

0

0 (type 1)

n.d.

0

0

n.d.

n.d.

negative

n.d.

26

Gait disturbance, unknown aetiology

0

4.9

0

0 (type 1)

n.d.

0

0

n.d.

n.d.

negative

n.d.

27

Orthostatic hypotension (normal brain MRI)

1

7.5

0

0 (type 1)

n.d.

0

0

0

0

negative

negative

28

Headache (brain CT negative)

0

3.2

0

0 (type 4)

n.d.

0

0

0

0

negative

negative

29

Vertigo

1

11.3

0

0 (type 4)

0

0

0

0

0

negative

negative

30

Peripheral facial palsy

1

4.0

0

0 (type 1)

0

0

0

0

0

negative

negative

31

Lyme arthritis

2

4.2

0

0 (type 4)

0

0

0

0

0

negative

negative

32

Polyneuropathy, lumbar disc prolapse

1

7.4

0

0 (type 4)

0

0

0

0

0

negative

negative

33

Paraprotein (UK NEQAS sample 8/2011)

n.d.

n.d.

n.d.

0**** (type 5)

0****

0

0****

0

0

negative

negative

  1. * IEF pattern type according to the international consensus classification [1, 15]
  2. ** paraprotein IgGκ detected
  3. *** the presence of only 1 CSF-restricted band was considered to be a negative finding
  4. **** paraprotein IgGλ detected
  5. Intrathecal Ig (IgG, IgM, IgA) fraction has been assessed according to Reiber's formula [14].