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Table 1 Population pharmacokinetic parameter estimates with the corresponding inter-individual coefficient of variation (CV%) and lower -and upper limit confidence intervals (LLCI and ULCI).

From: Evaluation of blood-brain barrier transport and CNS drug metabolism in diseased and control brain after intravenous L-DOPA in a unilateral rat model of Parkinson's disease

Parameter

Estimate

CV%

LLCI-ULCI

L-DOPA

   

Cl (mL/min)

30

21

17 - 43

ω2 Cl

0.26

59

-0.041 - 0.56

V1 (mL)

98

39

24 - 172

V2 (mL)

157

15

112 - 202

V3 (mL)

599

15

425 - 773

V4 (mL)

13300

25

6810 - 19800

ω2 V4

0.075

40

0.020 - 0.13

Q2 (mL/min)

22

24

11 - 32

Q3 (mL/min)

11

16

7.5 - 15

Q4 (mL/min)

22

14

16 - 29

Kin (min-1)

5.8

36

1.7 - 9.8

ω2 Kin

0.94

41

0.19 - 1.7

Proportional error (plasma)

0.087

15

0.061 - 0.113

Proportional error (ECF)

0.17

21

0.10 - 0.24

Control cerebral hemisphere

   

DOPAC

   

Formation k46 (min-1)

0.000044

28

0.000020 - 0.000068

ω2 k46

0.50

60

-0.084 - 1.1

k40 (min-1)

0.53

23

0.29 - 0.77

ω2 k40

0.42

46

0.045 - 0.80

Elimination k60 (min-1)

0.0053

17

0.0035 - 0.0071

ω2 k60

0.19

58

-0.025 - 0.41

Residual error (additive)

0.0020

16

0.0014 - 0.0026

HVA

   

Formation k47 (min-1)

0.000023

15

0.000016 - 0.000030

ω2 k47

0.019

70

-0.0070 - 0.000030

k40 (min-1)

0.19

16

0.13 - 0.25

k70 (min-1)

0.0044

12

0.0033 - 0.0054

ω2 k70

0.14

53

-0.006 - 0.28

Residual error (additive)

0.0028

24

0.0015 - 0.0041

Rotenone-treated responder cerebral hemisphere

  

DOPAC

   

Formation k58(min-1)

0.000054

51

-0.00000039 - 0.000011

ω2 k58

1.0

40

0.23 - 1.9

k50 (min-1)

0.36

55

-0.025 - 0.75

ω2 k50

0.53

36

0.16 - 0.90

Elimination k80 (min-1)

0.038

18

0.024 - 0.052

Residual error (additive)

0.0014

51

0.0000020 - 0.0027

HVA

   

Formation k59(min-1)

0.000016

42

0.0000028 - 0.000030

ω2 k59

0.49

65

-0.14 - 1.12

k50(min-1)

0.14

55

-0.010 - 0.29

Elimination k90 (min-1)

0.011

39

0.0027 - 0.020

Residual error (additive)

0.0034

41

0.00060 - 0.0061

  1. V = volume of distribution, Q = inter-compartmental clearance, k = elimination rate constant. Note: V5 = V4, Q5 = Q4 and k50 = k40.