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Figure 3 | Fluids and Barriers of the CNS

Figure 3

From: Evaluation of blood-brain barrier transport and CNS drug metabolism in diseased and control brain after intravenous L-DOPA in a unilateral rat model of Parkinson's disease

Figure 3

L-DOPA concentration-time profiles in brain ECF in the control cerebral hemisphere (○; in total 12 rats: 10 mg/kg, n = 4; 25 mg/kg, n = 3; 50 mg/kg, n = 5) and in the rotenone-treated responder cerebral hemisphere (•; in total 7 rats: 10 mg/kg, n = 1; 25 mg/kg, n = 2; 50 mg/kg, n = 4), obtained after a 20-min intravenous infusion in Lewis rats.

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Fluids and Barriers of the CNS

ISSN: 2045-8118