Figure 2From: Evaluation of blood-brain barrier transport and CNS drug metabolism in diseased and control brain after intravenous L-DOPA in a unilateral rat model of Parkinson's diseaseL-DOPA concentration-time profiles in plasma, obtained after a 20-min intravenous infusion in Lewis rats. Depicted are the observed concentrations (dots) and individual predictions (solid lines), separated by L-DOPA dose (in total 13 rats: 10 mg/kg, n = 4; 25 mg/kg, n = 4; 50 mg/kg, n = 5).Back to article page