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Figure 1 | Fluids and Barriers of the CNS

Figure 1

From: Evaluation of blood-brain barrier transport and CNS drug metabolism in diseased and control brain after intravenous L-DOPA in a unilateral rat model of Parkinson's disease

Figure 1

The population pharmacokinetic model for L-DOPA, DOPAC and HVA comprising of three compartments (1-3) describing the pharmacokinetics of L-DOPA in plasma, two compartments (4 and 5) describing the pharmacokinetics of L-DOPA in brain ECF , one for the control cerebral hemisphere and one for the rotenone-treated responder cerebral hemisphere, two compartments (6 and 8) describing the kinetics of DOPAC in brain ECF , one for the control cerebral hemisphere and one for the rotenone-treated responder cerebral hemisphere and two compartments (7 and 9) describing the kinetics of HVA in brain ECF , one for the control cerebral hemisphere and one for the rotenone-treated responder cerebral hemisphere. (V = volume of distribution, Q = inter-compartmental clearance, k = elimination rate constant, Kin = endogenous formation rate constant of L-DOPA.).

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