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Figure 9 | Fluids and Barriers of the CNS

Figure 9

From: Structural defects in cilia of the choroid plexus, subfornical organ and ventricular ependyma are associated with ventriculomegaly

Figure 9

BBS mutant mouse SFO ultrastructure. TEM micrographs of coronal sections of 3.5 wk-old wild-type (A), Bbs1M390R/M390R (B) and Bbs6−/− SFO show an intact ependymal layer with zona adherens junctions between cells and numerous motile cilia on the apical surface. Transition zones (arrows in C) appear normal in 8 mo.-old Bbs6−/− mice. Electron-dense and vesicle-like material is seen in Bbs1M390R/M390R and Bbs6−/− SFO cilia in the presence (G) and absence (D-F) of axonemal disruption. Arrows point to axonemes. Bars equal 2 μm (A, B,C) and 0.2 μm (D-H).

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Fluids and Barriers of the CNS

ISSN: 2045-8118