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Figure 1 | Fluids and Barriers of the CNS

Figure 1

From: Intrastriatal convection-enhanced delivery results in widespread perivascular distribution in a pre-clinical model

Figure 1

Widespread interstitial distribution of dextrans and co-localisation with leptomeningeal macrophages following CED. Figure A shows a low power micrograph of a coronal section through the right striatum of a rat prior to ED1 immunostaining (scale bar = 1 mm). Labelled are the right lateral ventricle (V), needle track (NT) and interstitial distribution of 150 kDa dextran at 3 h following CED (circled). High power micrographs of the area within the white box in Figure A illustrate co-localisation of 150 kDa dextran (green) with ED1-positive leptomeningeal macrophages (red) at 3 h (B, C and D, scale bar = 100 μm).

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