Mannan-binding lectin in cerebrospinal fluid: a leptomeningeal protein

Table 1 CSF/serum quotients for albumin, IgG, IgA, IgM and MBL with individual CSF and serum concentrations of MBL in controls and patients with barrier dysfunctions

	Normal Blood CSF Barrier function
Pat	Q Alb × 10³	Q IgG × 10³	Q IgA × 10³	Q IgM × 10³	Q MBL × 10³	MBL-CSF ng/ml	MBL-S ng/ml
1	6,8	2.9	1.5	0.3	2,77	1,1	397
2	3,4	1.6	0.6	0.1	1,33	1,31	979
3	6,0	2.9	1.5	<0.3	5,21	1,96	376
4	3,7	1.8	0.9	<0.2	0,39	0,2	514
5	7,0	3.2	1.9	0.3	16,7	0,2	12
6	4,9	2.3	0.8	0.2	0,34	1,58	4598
7	5,0	2.2	1.3	0.2	1,58	1,15	728
8	6,2	2.7	1.3	<0.3	0,53	0,11	207
9	2,6	1.2	0.6	<0.1	0,27	0,27	985
10	5,6	3.0	1.7	0.3	1,39	0,82	589
11	3,4	1.5	0.6	0.1	6,00	1,82	303
12	4,1	2.2	1.1	<0.3	0,77	0,7	913
13	7,5	4.2	2.6	0.5	33,8	1,15	34
Blood CSF barrier dysfunction
14	13.4	7.2	4.0	0.5	12.75	0.88	69
15	10.3	5.2	3.1	1.1	0.61	1.14	6784
16	16.6	9.6	7.7	1.2	0.59	1.59	2678
17	36.7	32.2	22.8	13.6	5.00	6.79	1346
18	64.6	52.5	42.4	36.6	2.41	4.19	1739
19	24.8	11.3	7.6	0.9	0.64	2.16	3391
20	106	79.7	70.2	67.9	4.39	8.43	1921

The control group (upper part) represents patients with normal CSF data and normal barrier function. The lower part represents the group of patients with a blood-CSF barrier dysfunction without signs of an inflammation in brain.

ISSN: 2045-8118