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Figure 6 | Fluids and Barriers of the CNS

Figure 6

From: Active induction of experimental autoimmune encephalomyelitis by MOG35-55 peptide immunization is associated with differential responses in separate compartments of the choroid plexus

Figure 6

Schematic summary of the induction of immune-related genes in the choroid plexus compartments following MOG-CFA/PTX versus CFA-PTX immunization. Depicted are qualitative ‘heat maps’ of overall modulation in immune-related gene expression patterns over time, within the separate CP stromal capillary (left) and CP choroidal epithelial (right) tissues after the two type immunization regimens. While CFA/PTX immunization alone induces expression of immune-related genes in both tissues, MOG-CFA/PTX immunization causes supernumerary stimulation above this level. The differences in gene expression between the immunization regimens highlight what might reflect gene changes specifically due to MOG-associated autoimmunity. The effects due solely to CFA/PTX immunization might reveal priming of the immune response that is necessary for the development of EAE.

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