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Table 1 Patient data and antibody indices to six viral antigens in CSF samples negative for total-IgG oligoclonal bands

From: Usefulness of antibody index assessment in cerebrospinal fluid from patients negative for total-IgG oligoclonal bands

No. Age Sex OCBs AI Bb AI HSV AI VZV AI CMV AI MV AI RV CSF WCC Suspected diagnosis and indicated by the sender
#1A 32 M NEG/NEG Not det. 0.72 0.74 Not det. 0.69 0.77 1557 CSF PCR positive HSV encephalitis
#1B 32 M NEG/NEG Not det. 43.40 1.24 Not det. ND ND 1456 CSF PCR positive HSV encephalitis, follow-up 19 days later
#1C 32 M NEG/NEG ND 53.40 16.30 # ND ND ND 152 CSF PCR positive HSV encephalitis, follow-up a further 3 days later
#2A 33 M NEG/NEG Not det. 2.02 1.54 ND ND 0.83 No data Blistering rash V2, peripheral facialis paresis
#2B 33 M NEG/NEG ND 1.94 1.39 ND ND ND 19 Blistering rash V2, peripheral facialis paresis, follow-up 8 days later
#3 30 M NEG/NEG ND 2.43 1.12 ND 0.85 1.10 2 No data available
#4 29 F NEG/NEG Not det. 2.12 0.99 1.30 ND 0.94 3 No data available
#5A 34 F NEG/NEG Not det. ND ND ND ND ND No data VZV meningoencephalitis
#5B 34 F NEG/NEG ND Not det. 3.99 Not det. ND ND 360 VZV meningoencephalitis, follow-up 5 days later
#6 60 F NEG/NEG Not det. 1.20 2.40 0.86 ND ND 2 “FK506-associated leukoencephalopathy”, grand mal
#7 51 M NEG/NEG 1.26 1.11 2.42 1.03 0.90 1.03 1 “Fatigue and apathy”
#8 42 M NEG/NEG Not det. 1.31 3.26 ND 1.03 1.32 3 “Possible multiple sclerosis“
#9 74 F NEG/NEG ND 1.43 2.30 Not det. ND 0.81 2 No data available
#10 50 F NEG/NEG ND Not det. 2.00 ND 0.85 0.67 No data No data available
#11 71 F POS/POS* 20.90 1.45 1.32 Not det. 0.97 0.91 4 Neuroborreliosis, encephalitis
#12A 34 F NEG/NEG 2.60 0.91 0.80 Not det. 0.70 0.80 82 Neuroborreliosis with abducens and facial nerve paresis
#12B 34 F NEG/NEG 1.70 0.91 0.95 Not det. 1.15 0.83 277 Confirmatory follow-up sample obtained 5 days later
#13 44 M NEG/NEG 10.60 0.90 1.00 0.88 1.5 ND No data "Aseptic Meningitis”
#14 84 M NEG/NEG 5.31 1.02 0.99 0.85 1.02 1.04 2 No data available
#15 34 F NEG/NEG 4.79 Not det. 0.99 Not det. 0.92 ND 1 No data available
#16 57 M NEG/NEG 3.30 0.96 0.88 1.20 0.76 0.75 1 No data available
#17 21 M NEG/NEG 2.50 Not det. 0.85 Not det. ND 0.85 1 No data available
#18 38 F NEG/NEG ND 1.67 1.00 2.40 0.44 0.94 No data “Encephalitis”
#19 40 F NEG/NEG Not det. Not det. 16.20 1.43 0.72 0.90 No data No data available
#20 25 F NEG/NEG Not det. 0.92 1.00 Not det. ND 2.10 1 “Clinically possible multiple sclerosis (Poser)”
#21 60 M NEG/NEG ND 0.85 0.87 Not det. 2.80 0.92 No data No data available
  1. AI = antibody index; Bb = Borrelia burgdorferi; CMV = cytomegalovirus; HSV = herpes simplex virus; MV = measles virus; NEG/NEG = negative in CSF/negative in serum; not det. = not detectable; ND = not done; OCBs = oligoclonal bands; RV = rubella virus; VZV = varicella zoster virus. * Mirror pattern (so-called “pattern 4” according to an international consensus on OCB diagnostics) in the absence of CSF-restricted IgG bands. # Cross-reactivity between HSV and VZV as a result of epitope spreading (see reference [2]).