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Figure 1 | Fluids and Barriers of the CNS

Figure 1

From: Ecrg4 expression and its product augurin in the choroid plexus: impact on fetal brain development, cerebrospinal fluid homeostasis and neuroprogenitor cell response to CNS injury

Figure 1

ECRG4 homologies and its predicted processing: A: ECRG4 encodes conserved, potentially secreted proteins. Homologies between species of Ecrg4 encoded proteins are evident after the primary sequence alignment of the proteins encoded by mouse, rat, human, chimpanzee, dog, cow, chicken and zebrafish Ecrg4(a) gene were collated from Pubmed (nucleotide) and compared. To aid in functional comparisons, the sequences were labeled red for small amino acids, blue for acidic and magenta for basic amino acids, green for hydroxyl-, sulfhydryl, aminated or glycine amino acids. Actual homologies are presented in table 1. Consensus processing sites for (1) removal of the signal peptide, (2) processing by furin-like hormone substrates and (3) thrombin is highlighted by a line over the sequences. B: Candidate proteins generated from Ecrg4 gene expression. Eight potential protein products are predicted by algorithms to be generated from the single gene: intact Ecrg4(1-148); its leader sequence, augurin, argilin and ecilin and their ∆16C-terminal cleaved homologs: C∆16-augurin, C∆16-argilin and the ∆16 peptide itself.

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Fluids and Barriers of the CNS

ISSN: 2045-8118