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Figure 9 | Fluids and Barriers of the CNS

Figure 9

From: The pulsating brain: A review of experimental and clinical studies of intracranial pulsatility

Figure 9

Rounding of the intracranial pulse wave as a result of increased ICP. Elevated ICP leads to decreased intracranial compliance, which investigators have found to result in amplification of the lower harmonic content of the intracranial pulse pressure wave, relative to the higher harmonic component. This behavior appears as a rounding of the pulse wave demonstrated here by CSF volume loading in the dog (upper panel: normal ICP levels, lower panel: raised ICP condition). The data also illustrate the timing, or phase, difference between the ABP and ICP waveforms, and the phase change with changes with mean ICP (figure reproduced with permission from Wagshul et al [74]).

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