Figure 4

Comparison of the carrier-mediated clearance of [¹⁴C]GlySar, [³H]cefadroxil, L-[³H]kyotorphin (L-KTP) from CSF after intracerebroventricular administration to Pept2^-/- (KO) and Pept2^+/+ (WT) mice [31, 32]. A half-life for the clearance of these compounds (corrected for diffusion using radiolabeled mannitol) was calculated and the KO values expressed as a % of WT. Note the prolonged half-life for each of the compounds in the KO mice reflecting reduced CP-mediated clearance.