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Figure 4 | Fluids and Barriers of the CNS

Figure 4

From: Choroid plexus transport: gene deletion studies

Figure 4

Comparison of the carrier-mediated clearance of [14C]GlySar, [3H]cefadroxil, L-[3H]kyotorphin (L-KTP) from CSF after intracerebroventricular administration to Pept2-/- (KO) and Pept2+/+ (WT) mice [31, 32]. A half-life for the clearance of these compounds (corrected for diffusion using radiolabeled mannitol) was calculated and the KO values expressed as a % of WT. Note the prolonged half-life for each of the compounds in the KO mice reflecting reduced CP-mediated clearance.

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