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Figure 3 | Fluids and Barriers of the CNS

Figure 3

From: Choroid plexus transport: gene deletion studies

Figure 3

The uptake of [14C]GlySar, [3H]cefadroxil, [3H]carnosine and [14C]5-ALA into CSF and cortex after intravenous administration into Pept2-/- (KO) and Pept2+/+ (WT) mice [2730]. For both genotypes, CSF/plasma and cortex/plasma ratios were calculated to account for differences in plasma concentrations which were lower in the KO mice because of reduced renal reabsorption of these peptides/peptidomimetics. The KO ratios were then expressed as a % of WT. Note the marked increase in CSF uptake for all 4 substrates in the KO while the effect on cortex was more modest (GlySar, cefadroxil), absent (5-ALA) or even reversed (carnosine).

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