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Figure 5 | Fluids and Barriers of the CNS

Figure 5

From: Magnetic resonance imaging indicators of blood-brain barrier and brain water changes in young rats with kaolin-induced hydrocephalus

Figure 5

Magnetic resonance and fluorescent tracer permeability in hydrocephalic rat brain. MR images and fluorescence microscopy images from a rat that received kaolin injection 1 week earlier. A: Calculated difference MR image obtained 20 min after Gd-DTPA injection through posterior cerebrum and midbrain demonstrating pixels with intensity that increased > 20%. B: Magnification of enhanced signal region in the inferior parietal region (arrow), which suggests that there is BBB disruption with extravasation of Gd-DTPA. C: Photomicrograph of tissue corresponding to signal-enhanced region in B. There is focal diffusion of 10kDa Texas Red tracer into tissue surrounding a vein. D: There is no extravasation of 500kDa Fluorescein green tracer in this area (arrow). Bar = 50 μm.

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Fluids and Barriers of the CNS

ISSN: 2045-8118