Skip to main content
Figure 5 | Fluids and Barriers of the CNS

Figure 5

From: 1α,25-Dihydroxyvitamin D3 enhances cerebral clearance of human amyloid-β peptide(1-40) from mouse brain across the blood-brain barrier

Figure 5

Effect of forskolin on amount of [125I]hAβ(1-40) remaining in the ipsilateral cerebrum. Mice received i.p. injection of forskolin (2.3 and 23 μg dissolved in 100 μL of H2O containing 25% DMSO) or vehicle (V, 100 μL of H2O containing 25% DMSO). After 24 h, a mixture of [125I]hAβ(1-40) (0.012 μCi) and [3H]dextran (0.12 μCi) dissolved in 0.30 μL of ECF buffer was injected into the S2 region of the brain. Data, obtained at 60 min after intracerebral microinjection, are presented as the mean ± SEM (n = 4 - 5). *p < 0.05, significantly different from vehicle-treated group.

Back to article page