Figure 1
Effect of 1,25(OH) 2 D3 on the elimination rate of [125I]hAβ(1-40) from mouse brain. Mice received i.p. injection of 1,25(OH)2D3 (1 μg dissolved in 100 μL of H2O containing 5% ethanol, solid circles) or vehicle (100 μL of H2O containing 5% ethanol, open circles). After 24 h, a mixture of [125I]hAβ(1-40) (0.012 μCi) and [3H]dextran (0.12 μCi) dissolved in 0.30 μL of ECF buffer was injected into the S2 region of the brain. The solid line was obtained with the non-linear least-squares regression analysis program, MULTI. Each point represents the mean ± SEM (n = 3 - 5). (B) The elimination rate constant of [125I]hAβ(1-40) from mouse brain after treatment with 1,25(OH)2D3 (D3) or vehicle (V). Each bar represents the mean ± SD (n = 3 - 5). **p < 0.01, significantly different from vehicle-treated group.