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Table 1 Demographic data and results for vascular and CSF flows in four groups

From: Cerebrospinal fluid and blood flow in mild cognitive impairment and Alzheimer's disease: a differential diagnosis from idiopathic normal pressure hydrocephalus

Characteristic HEVs aMCI AD NPH P-value
Number of subjects 12 10 9 13 NS
Age (years) 71 ± 9 78 ± 7 79 ± 5 70 ± 6 NS
Disease duration (months) / 27 ± 18 29 ± 11.4 24 ± 15 NS
MMSE 29 ± 2 26 ± 3 21 ± 3 ND <0.05
BPM 78 ± 10 65 ± 8 72 ± 8 73 ± 15 NS
tCBF (ml/min) 509 ± 108 638 ± 126 560 ± 83 450 ± 129 <0.01
API 59 ± 12 119 ± 69 107 ± 50 93 ± 42 <0.05
Arterial pulse volume (ml) 0.8 ± 0.3 1.4 ± 0.4 1 ± 0.3 0.8 ± 0.4 <0.01
VBF (ml/min) 367 ± 130 522 ± 157 457 ± 71 361 ± 92 0.01
AV stroke volume (ml/CC) 0.7 ± 0.3 1.3 ± 0.3 1 ± 0.5 0.9 ± 0.4 0.01
AV delay (% of CC) 18 ± 6 12 ± 6 8 ± 7 10 ± 4 <0.01
Cervical stroke volume (μl/CC) 457 ± 154 584 ± 152 450 ± 221 455 ± 133 NS
Aqueductal stroke volume (μl/CC) 34 ± 17 73 ± 33 39 ± 18 167 ± 89 <0.01
  1. Results are given for four groups: (i) healthy elderly volunteers (HEVs) and patients with (ii) amnesic mild cognitive impairment (a-MCI), (iii) Alzheimer's disease (AD) and (iv) normal pressure hydrocephalus (NPH). Values are expressed as the mean ± standard deviation. MMSE: Mini Mental State Examination; BPM: heart rate in beats per minute; tCBF: total cerebral arterial blood flow; API: arterial pulsatility index; VBF: venous blood flow; AV: arteriovenous; ml: millilitre; μl: microlitre; min: minute; CC: cardiac cycle.
  2. The threshold for statistical significance was set to p < 0.05; NS: not significant.