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Table 1 Demographic data and results for vascular and CSF flows in four groups

From: Cerebrospinal fluid and blood flow in mild cognitive impairment and Alzheimer's disease: a differential diagnosis from idiopathic normal pressure hydrocephalus

Characteristic

HEVs

aMCI

AD

NPH

P-value

Number of subjects

12

10

9

13

NS

Age (years)

71 ± 9

78 ± 7

79 ± 5

70 ± 6

NS

Disease duration (months)

/

27 ± 18

29 ± 11.4

24 ± 15

NS

MMSE

29 ± 2

26 ± 3

21 ± 3

ND

<0.05

BPM

78 ± 10

65 ± 8

72 ± 8

73 ± 15

NS

tCBF (ml/min)

509 ± 108

638 ± 126

560 ± 83

450 ± 129

<0.01

API

59 ± 12

119 ± 69

107 ± 50

93 ± 42

<0.05

Arterial pulse volume (ml)

0.8 ± 0.3

1.4 ± 0.4

1 ± 0.3

0.8 ± 0.4

<0.01

VBF (ml/min)

367 ± 130

522 ± 157

457 ± 71

361 ± 92

0.01

AV stroke volume (ml/CC)

0.7 ± 0.3

1.3 ± 0.3

1 ± 0.5

0.9 ± 0.4

0.01

AV delay (% of CC)

18 ± 6

12 ± 6

8 ± 7

10 ± 4

<0.01

Cervical stroke volume (ÎĽl/CC)

457 ± 154

584 ± 152

450 ± 221

455 ± 133

NS

Aqueductal stroke volume (ÎĽl/CC)

34 ± 17

73 ± 33

39 ± 18

167 ± 89

<0.01

  1. Results are given for four groups: (i) healthy elderly volunteers (HEVs) and patients with (ii) amnesic mild cognitive impairment (a-MCI), (iii) Alzheimer's disease (AD) and (iv) normal pressure hydrocephalus (NPH). Values are expressed as the mean ± standard deviation. MMSE: Mini Mental State Examination; BPM: heart rate in beats per minute; tCBF: total cerebral arterial blood flow; API: arterial pulsatility index; VBF: venous blood flow; AV: arteriovenous; ml: millilitre; μl: microlitre; min: minute; CC: cardiac cycle.
  2. The threshold for statistical significance was set to p < 0.05; NS: not significant.
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Fluids and Barriers of the CNS

ISSN: 2045-8118