Kaolin-induced chronic hydrocephalus accelerates amyloid deposition and vascular disease in transgenic rats expressing high levels of human APP

Table 1 Summary of experimental animals and histological findings

Duration	Group	N	Ventricular Enlargement	Histiocytic & Granulomatous Inflammation	Neuronal Aβ40	Neuronal Aβ42	Neuronal Oligomeric Aβ	Vascular Pathology	Ischemic Infarcts
6 mo. + 10 wk.	Kaolin	4	++	+++	++	-	++	++	-
6 mo. + 10 wk.	Sham	2	-	-	+	-	+	+	-
6 mo. + 10 wk.	Naïve	2	-	-	+	-	+	+	-
6 mo. + 6 mo.	Kaolin	3	+	+	++	-	+++	++	-
6 mo. + 6 mo.	Sham	2	-	-	+	-	++	+	-
6 mo. + 6 mo.	Naïve	2	-	-	+	-	++	+	-
12 mo. + 10 wk.	Kaolin	4	++	+++	++	-	+++	+++	-
12 mo. + 10 wk.	Sham	2	-	-	+	-	++	+	-
12 mo. + 10 wk.	Naïve	2	-	-	+	-	++	+	-
12 mo. + 6 mo.	Kaolin	2	+	+	+++	-	+++	+++	+
12 mo. + 6 mo.	Sham	2	-	-	+	-	++	+	-
12 mo. + 6 mo.	Naïve	1	-	-	+	-	++	+	-
12 mo. to natural end-of-life	Kaolin	3	+	+	+++	-	+++	+++	++
12 mo. to natural end-of-life	Sham	2	-	-	+	-	++	++	-
12 mo. to natural end-of-life	Naïve	2	-	-	+	-	++	++	-

The pathology and morphological changes, as observed in histochemically-stained sections, were qualitatively graded using a scale ranging from no detectable changes (−) to mild (+), moderate (++), or severe (+++) changes.

ISSN: 2045-8118