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Figure 7 | Fluids and Barriers of the CNS

Figure 7

From: Kaolin-induced chronic hydrocephalus accelerates amyloid deposition and vascular disease in transgenic rats expressing high levels of human APP

Figure 7

Deposition of Aβ40 in brain parenchymal vessels (arrows). Top row: six-month-old tgAPP21 rat. (A) sham-operated age-matched control, x200. (B) Hydrocephalic tgAPP21 rat 10 weeks post kaolin injection, ×200. Note a moderate increase in immunoreactivity in the vessels of the hydrocephalic rat compared to control. Bottom row: 12-month-old tgAPP21 rat. (C) Age-matched, sham-operated control showing minimal vascular Aβ immunostaining, x200. (D) 12-month-old tgAPP21 rat 10 weeks after hydrocephalus induction showing marked deposition of Aβ in vessel walls, ×200.

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Fluids and Barriers of the CNS

ISSN: 2045-8118